Studies on Chloramphenicol. II

X-ray studies on phospholipid bilayers. XI. Interactions with chloramphenicol.

Chloramphenicol is a widely used antibiotic with low levels of toxicity. However, scanning electron microscopy revealed morphological changes in human erythrocytes when they interacted in vitro with therapeutical concentrations of chloramphenicol. To explain this shape change, a study concerned with the possible interactions of this antibiotic with bilayers built-up of phospholipids located in ...

Chloramphenicol.

Chloramphenicol (chloromycetin), an Antibiotic. Pharmacological and Pathological Studies in Animals.

It is a neutral white crystalline substance with a bitter taste and is stable in neutral and acid solutions. The drug is moderately soluble in water (0.25 per cent at room temperature, 0.65 per cent at 700 C and up to 15 per cent in propylene glycol, 5 per cent in 50 per cent acetamide), and is insoluble in vegetable oils. Solubility in urine or serum is about the same as in water. Solutions ar...

BIOCHEMICAL STUDIES ON CHLORAMPHENICOL (CHLOROMYCETIN*) III. ISOLATION AND IDENTIFICATION OF METABOLIC PRODUCTS IN URINEt

When chloramphenicol is administered by mouth to normal human subjects, only 5 to 10 per cent of the administered dose is excreted unchanged in the urine, as determined by microbiological assay methods (3, 4). However, with calorimetric methods for aromatic nitro compounds (5), from 75 to 90 per cent of the administered dose is accounted for in 24 hour urinary excretion in man (3). The major po...

Studies on Echinococcosis : Ii. Echinococcosis in Japan